Effect of atorvastatin on expression of TLR4 and NF-κB p65 in atherosclerotic rabbits
Asian Pacific Journal of Tropical Medicine
;
(12): 493-496, 2013.
Article
in English
| WPRIM
| ID: wpr-820014
ABSTRACT
OBJECTIVE@#To study the effect of atorvastatin on atherosclerotic rabbits.@*METHODS@#A total of 60 New Zealand male rabbits were randomly divided into the normal group, model group and atorvastatin group. The replication rabbit atherosclerotic model with immune injury combined with a high fat diet feeding was used. All rabbits were sacrificed after 3 months. TLR4 and NF-κB p65 were observed by HE staining, immunohistochemistry and western blotting.@*RESULTS@#The expression of TLR4, NF-κB p65 were significantly increased in the model group compared with the normal group. The expression of TLR4 and NF-κB p65 decreased significantly in the atorvastatin group, and there was no difference compared with the normal group.@*CONCLUSIONS@#The effect of atorvastatin on atherosclerosis may be achieved by the inhibition of the expression of TLR4 and NF-κB p65.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aorta
/
Pharmacology
/
Pyrroles
/
Blood
/
Random Allocation
/
Gene Expression
/
Disease Models, Animal
/
Drug Therapy
/
Atherosclerosis
/
Transcription Factor RelA
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2013
Type:
Article
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