Correlation of chronic periodontitis in tropical area and IFN-γ, IL-10, IL-17 levels
Asian Pacific Journal of Tropical Medicine
;
(12): 489-492, 2013.
Article
in English
| WPRIM
| ID: wpr-820015
ABSTRACT
OBJECTIVE@#To evaluate the correlation of chronic periodontitis in tropical area and IFN-γ, IL-10 and IL-17 levels.@*METHODS@#One hundred and forty-eight patients and one hundred and thirty-two healthy control subjects were included in the study. Clinical parameters (PI, GI and PD) and GCF levels of IFN-γ, IL-10 and IL-17 were measured at baseline, week 8, week 16 and week 24 after mechanical removal of dental plaque. IFN-γ and IL-10 were determined with ELISA methods and IL-17 was determined with the cytometric bead array.@*RESULTS@#Removal of dental plaque resulted in improvement in all clinical parameters. Meanwhile, GCF IL-17 declined to control levels, while GCF IFN-γ and IL-10 levels remained unchanged.@*CONCLUSIONS@#The decline of GCF IL-17 levels in patients with resolution of periodontitis suggests that IL-17 is involved in the periodontal inflammatory process.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Tropical Climate
/
Case-Control Studies
/
Chemistry
/
China
/
Epidemiology
/
Gingival Crevicular Fluid
/
Dental Scaling
/
Interferon-gamma
/
Interleukin-10
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2013
Type:
Article
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