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Antidiabetic activity of alcoholic leaves extract of Alangium lamarckii Thwaites on streptozotocin-nicotinamide induced type 2 diabetic rats
Asian Pacific Journal of Tropical Medicine ; (12): 904-909, 2011.
Article in English | WPRIM | ID: wpr-820038
ABSTRACT
OBJECTIVE@#To investigate antidiabetic potential of alcoholic leaves extract of Alangium lamarckii (A. lamarckii) on streptozotocin-nicotinamide induced type 2 diabetic rats.@*METHODS@#Oral glucose tolerance test was done by inducing hyperglycemic state via administration of glucose in water (2g/kg). Single dose of alcoholic leaves extract of A. lamarckii (250 and 500 mg/kg, p.o.) were administered to normoglycemic, hyperglycemic rats. Type 2 diabetes was induced by single intraperitoneal injection of nicotinamide (110 mg/kg) followed by streptozotocin (65mg/kg). The study also included estimations of blood plasma glucose, lipid profile, liver glycogen, body weight and antioxidant status in normal and diabetic rats.@*RESULTS@#Admistration of alcoholic extract of A. lamarckii at two dosage 250 and 500 mg/kg, p.o. did not showed any significant change in blood glucose level of normoglycemic rats (P>0.05), whereas, oral glucose tolerance test depicted reduction in blood glucose level (P<0.05). The streptozotocin-nicotinamide induced diabetic rats, significantly decreased the blood plasma glucose level (P<0.001) comparable to glibenclamide (10 mg/kg), restored the lipid profile and showed improvement in liver glycogen, body weight and antioxidant status in diabetic rats.@*CONCLUSIONS@#Present finding demonstrated the significant antidiabetic activity of alcoholic leaves extract of A. lamarckii.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Superoxide Dismutase / Blood / Blood Glucose / Body Weight / Plant Extracts / Chemistry / Treatment Outcome / Streptozocin / Niacinamide / Plant Leaves Limits: Animals Language: English Journal: Asian Pacific Journal of Tropical Medicine Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Superoxide Dismutase / Blood / Blood Glucose / Body Weight / Plant Extracts / Chemistry / Treatment Outcome / Streptozocin / Niacinamide / Plant Leaves Limits: Animals Language: English Journal: Asian Pacific Journal of Tropical Medicine Year: 2011 Type: Article