Serum EGF and NGF levels of patients with brain injury and limb fracture
Asian Pacific Journal of Tropical Medicine
;
(12): 383-386, 2013.
Article
in English
| WPRIM
| ID: wpr-820512
ABSTRACT
OBJECTIVE@#To explore the expression and significance of human epidermal growth factor (EGF) and nerve growth factor (NGF) in patients with knee osteoarthritis.@*METHODS@#RT-PCR and enzyme-linked immunosorbent assay were used to measure the serum EGF and NGF expression levels of patients with limb fracture and brain trauma injurry after 1 d, 3 d, 7 d, 14 d and the relationship between them was analyzed. The level was compared among the simple fracture group, traumatic brain injury group and the normal control group, with 40 cases in each group.@*RESULTS@#The serum NGF levels were significantly different among three groups. Serum NGF, EGF mRNA and protein levels gradually decreased with the increasing injury time in the limb fracture combined with brain injury group, traumatic brain injury group, the simple fracture group and the health control group (P<0.05).@*CONCLUSIONS@#The serum of NGF, EGF levels significantly increased when limb fracture combined with brain injury, so EGF and NGF may be involved in the process of fracture healing.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Blood
/
Brain Injuries
/
RNA, Messenger
/
Case-Control Studies
/
Chi-Square Distribution
/
Fracture Healing
/
Nerve Growth Factor
/
Epidermal Growth Factor
/
Fractures, Bone
Type of study:
Observational study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2013
Type:
Article
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