Expression of NF-κB and osteopontin of synovial fluid of patients with knee osteoarthritis
Asian Pacific Journal of Tropical Medicine
;
(12): 379-382, 2013.
Article
in English
| WPRIM
| ID: wpr-820513
ABSTRACT
OBJECTIVE@#To explore the significance of osteopontin and nuclear factor κB (NF-κB) expression in patients with knee osteoarthritis.@*METHODS@#RT-PCR and enzyme-linked immunosorbent assay were used to measure the Osteopontin (OPN) and NF-κB concentration of knee joint synovial fluid of patients with knee osteoarthritis and trauma fractures, and analyze the relationship between the expressiones of them.@*RESULTS@#OPN and NF-κB expression at the mRNA and protein levels of patients with knee osteoarthritis were significantly higher than the control group. the result showed statistical significance (P<0.05). There was a positive correlation between the OPN levels in synovial fluid of patients with knee osteoarthritis and NF-κB expression levels (P<0.05).@*CONCLUSIONS@#The high expression of OPN and NF-κB are closely related to occurrence and development of knee osteoarthritis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Synovial Fluid
/
RNA, Messenger
/
Case-Control Studies
/
Blotting, Western
/
Polymerase Chain Reaction
/
NF-kappa B
/
Statistics, Nonparametric
/
Osteoarthritis, Knee
/
Osteopontin
/
Genetics
Type of study:
Observational study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2013
Type:
Article
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