Wound healing effect of flavonoid rich fraction and luteolin isolated from Martynia annua Linn. on streptozotocin induced diabetic rats
Asian Pacific Journal of Tropical Medicine
;
(12): 253-259, 2013.
Article
in English
| WPRIM
| ID: wpr-820529
ABSTRACT
OBJECTIVE@#To evaluate wound healing potential of flavonoid fractions of Martynia annua (M. annua) Linn. leaves in diabetic rats on the basis of folkloric information and preliminary study.@*METHODS@#The flavonoid compound luteolin and apigenin were isolated from dried leaves of plant by column chromatography. The two concentrations (0.2% and 0.5% w/w) of luteolin and flavonoid fraction were selected for topically applied as ointment on diabetic wound. The Povidone Iodine Ointment USP was used as a reference. On 18th days, protein content, hydroxyproline and antioxidants (SOD, CAT and GSH) level in granuloma tissues were determined.@*RESULTS@#The results showed that, percent wound contraction were observed significantly (P<0.01) greater in MAF fraction and 0.5% w/w of luteolin treatment groups. Presence of matured collagen fibres and fibroblasts with better angiogenesis were observed in histopathological studies.@*CONCLUSIONS@#In conclusion, our findings suggest that flavonoid fraction (MAF) and luteolin (0.5% w/w) may have potential benefit in enhancing wound healing in diabetic condition, possibly due to free-radical scavenging activity of plant.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ointments
/
Pathology
/
Pharmacology
/
Skin
/
Wound Healing
/
Flavonoids
/
Administration, Cutaneous
/
Plant Extracts
/
Proteins
/
Chemistry
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2013
Type:
Article
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