GRK6 expression in patients with hepatocellular carcinoma
Asian Pacific Journal of Tropical Medicine
; (12): 220-223, 2013.
Article
in En
| WPRIM
| ID: wpr-820538
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the expression and potential roles of G protein-coupled receptor kinase 6 (GRK6) in hepatocellular carcinoma (HCC) patients.@*METHODS@#Immunohistochemistry and Western blot was performed to determine GRK6 expression in 73 HCC samples. And the correlation with clinicopathological features was also analyzed.@*RESULTS@#GRK6 expression was significantly higher in HCC than that in normal hepatic tissue. GRK6 was positively correlated with proliferation marker Ki-67, clinical stage, metastasis and survival time.@*CONCLUSIONS@#Our results suggested that GRK6 overexpression plays an important role in HCC. Monitoring the expression of GRK6 maybe helpful in early diagnosis and prognosis of HCC.
Full text:
1
Index:
WPRIM
Main subject:
Prognosis
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Biomarkers, Tumor
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Blotting, Western
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Risk Factors
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Carcinoma, Hepatocellular
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Ki-67 Antigen
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G-Protein-Coupled Receptor Kinases
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Liver Neoplasms
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Metabolism
Type of study:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Limits:
Adult
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Aged
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Female
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Humans
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Male
Language:
En
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2013
Type:
Article