GRK6 expression in patients with hepatocellular carcinoma
Asian Pacific Journal of Tropical Medicine
;
(12): 220-223, 2013.
Article
in English
| WPRIM
| ID: wpr-820538
ABSTRACT
OBJECTIVE@#To investigate the expression and potential roles of G protein-coupled receptor kinase 6 (GRK6) in hepatocellular carcinoma (HCC) patients.@*METHODS@#Immunohistochemistry and Western blot was performed to determine GRK6 expression in 73 HCC samples. And the correlation with clinicopathological features was also analyzed.@*RESULTS@#GRK6 expression was significantly higher in HCC than that in normal hepatic tissue. GRK6 was positively correlated with proliferation marker Ki-67, clinical stage, metastasis and survival time.@*CONCLUSIONS@#Our results suggested that GRK6 overexpression plays an important role in HCC. Monitoring the expression of GRK6 maybe helpful in early diagnosis and prognosis of HCC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Biomarkers, Tumor
/
Blotting, Western
/
Risk Factors
/
Carcinoma, Hepatocellular
/
Ki-67 Antigen
/
G-Protein-Coupled Receptor Kinases
/
Liver Neoplasms
/
Metabolism
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2013
Type:
Article
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