Expression and significance of VEGF and p53 in degenerate intervertebral disc tissue
Asian Pacific Journal of Tropical Medicine
;
(12): 79-81, 2013.
Article
in English
| WPRIM
| ID: wpr-820562
ABSTRACT
OBJECTIVE@#To investigate the mechanism of expression and significance of vascular endothelial growth factor (VEGF) and p53 in degenerate intervertebral disc tissue.@*METHODS@#Pathological sections collected from 156 patients with lumbar disc herniation after surgery were tested by immunohistochemistry method, for evaluation of the expression of VEGF and p53 in degenerate intervertebral disc tissue.@*RESULTS@#98 cases (62.8%) with vascular infiltration phenomenon are found, and positive rates of VEGF and p53 in degenerate intervertebral disc tissue are 73.42% (116/156) and 58.97% (92/156); co-expression rate is 53.2%(83/156); the expression rates of VEFG and p53 are significantly higher in the tissue with blood vessel infiltration than in the tissue without infiltration; there is a close relationship of VEGF with p53.@*CONCLUSIONS@#VEGF and p53 gene synergetic express in degenerate intervertebral disc tissue, working together in neovascularization and infiltration, and accelerating intervertebral disc tissue degeneration.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Immunohistochemistry
/
Case-Control Studies
/
Chi-Square Distribution
/
Tumor Suppressor Protein p53
/
Vascular Endothelial Growth Factor A
/
Intervertebral Disc Degeneration
/
Intervertebral Disc
/
Metabolism
Type of study:
Observational study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2013
Type:
Article
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