Dauricine can inhibit the activity of proliferation of urinary tract tumor cells
Asian Pacific Journal of Tropical Medicine
;
(12): 973-976, 2012.
Article
in English
| WPRIM
| ID: wpr-820583
ABSTRACT
OBJECTIVE@#To explore the anti-tumor effects of asiatic moonseed rhizome extraction-dauricine on bladder cancer EJ cell strain, prostate cancer PC-3Mcell strain and primary cell culture system.@*METHODS@#The main effective component-phenolic alkaloids ofMenispermum dauricum was extracted and separated from asiatic moonseed rhizome by chemical method. MTT method was used to detect dauricine anti-tumor effect.@*RESULTS@#Dauricine had an obvious proliferation inhibition effect on the main tumor cells in urinary system. The minimum drug sensitivity concentration was between 3.81-5.15 μg/mL, and the inhibition ratio increased with the increase of concentration.@*CONCLUSIONS@#Dauricine, the main effective component extracted from asiatic moonseed rhizome, had a good inhibition effect on tumor cells in urinary system. At the same time, Dauricine has certain inhibition effects on the primary cultured tumor cell.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Urinary Bladder Neoplasms
/
Pharmacokinetics
/
Plant Extracts
/
Chemistry
/
Rhizome
/
Menispermum
/
Cell Line, Tumor
/
Benzylisoquinolines
Limits:
Humans
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2012
Type:
Article
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