Effect of Yinxieling decoction on PASI, TNF-α and IL-8 in patients with psoriasis vulgaris
Asian Pacific Journal of Tropical Medicine
;
(12): 668-670, 2014.
Article
in English
| WPRIM
| ID: wpr-820634
ABSTRACT
OBJECTIVE@#To study the effect of Yinxieling decoction on PASI, TNF-α and IL-8 in patients with psoriasis vulgaris.@*METHODS@#A total of 120 cases of psoriasis vulgaris were divided into 4 groups according to syndrome differentiation of TCM and randomized controlled method:
wind heat syndrome group (group A), blood stasis syndrome group (group B), blood dryness syndrome group (group C) and control group (group D) (n=30 per group). Patients in observation groups were treated with Yinxieling decoction, while patients in control group were treated by placebo for 8 weeks. Levels of TNF-α and IL-8 were determined before treatment, 4 and 8 weeks after treatment. psoriasis area and severity index score was also performed before and after treatment.@*RESULTS@#psoriasis area and severity index score and serum level of TNF-α, IL-8 were significantly decreased in all groups. The decrease in three observation groups was more significant (P<0.05 or P<0.01), and the decrease in wind heat syndrome group was the most significant (P<0.01). psoriasis area and severity index was positively correlated with TNF-α and IL-8, respectively (P<0.05).@*CONCLUSIONS@#Yinxieling decoction has therapeutical effect on psoriasis vulgaris via regulating TNF-α and IL-8.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Psoriasis
/
Blood
/
Severity of Illness Index
/
Drugs, Chinese Herbal
/
Epidemiology
/
Interleukin-8
/
Tumor Necrosis Factor-alpha
/
Treatment Outcome
/
Classification
Type of study:
Controlled clinical trial
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2014
Type:
Article
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