Prevention effect of medical self-crosslinking sodium hyaluronate gel on epidural scar adhesion after laminectomy
Asian Pacific Journal of Tropical Medicine
;
(12): 501-504, 2014.
Article
in English
| WPRIM
| ID: wpr-820662
ABSTRACT
OBJECTIVE@#To analyze the effect and medical self-crosslinking sodium hyaluronate gel on epidural scar adhesion after laminectomy.@*METHODS@#A total of 24 New Zealand L5 laminectomy rabbits were randomly divided into four groups, group A as the control group without any treatment; group B covered by sodium hyaluronate gel; group C and group D covered by 0.5 and 1.0 mL medical self-crosslinking sodium hyaluronate gel. All rabbits were scored at various time points after 2, 4, 6, 8, 12 weeks, then the formation of scar was observed.@*RESULTS@#In Groups B, C, D loose scar tissue occurred after 2 weeks of the operation, scar tissues were significantly less than that in group A, with mild inflammatory reaction. After 8 weeks, the scar tissues of group B were significantly more than that of groups C, D. After two weeks, group B, C were back to the preoperative level; After 4 weeks, group D was back to the preoperative level; After four weeks, the CSEP of group A was increased significantly, which was significantly higher than that in groups B, C, D. The motor function score of group A, group B and group C were the same as preoperative, but that in group D it was decreased significantly, and then it gradually recovered. After 4 weeks it kept a stable level. The motor function score of group A was decreased gradually after the operation, which kept a stable level after 4 weeks, the motor function score was significantly lower than that in groups B, C, D.@*CONCLUSIONS@#Determination of somatosensory evoked potentials is sensitive indicator of spinal cord injury; Application of medical self-crosslinking sodium hyaluronate gel is effective on epidural scar adhesion after laminectomy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Postoperative Complications
/
General Surgery
/
Tissue Adhesions
/
Cicatrix
/
Therapeutic Uses
/
Drug Therapy
/
Epidural Space
/
Hyaluronic Acid
/
Laminectomy
Limits:
Animals
Language:
English
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2014
Type:
Article
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