Expression and distribution of TNF-α and PGE2 of periodontal tissues in rat periodontitis model
Asian Pacific Journal of Tropical Medicine
; (12): 412-416, 2014.
Article
in En
| WPRIM
| ID: wpr-820694
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To simulate the expression of TNF-α and PGE2 of periodontal tissues in rat periodontitis model.@*METHODS@#40 Wistar rats were randomly divided into the periodontitis group and the control group (n=20). After the successful establishment of periodontitis rat model, raising for six weeks before the animals were sacrificed. The periodontal tissues were obtained and made into slices. Observed the histopathological changes of the periodontal tissues and measured TNF-α, PGE2 levels change by immunohistochemistry, Western blot analysis and ELISA.@*RESULTS@#TNF-α, PGE2 expression of the periodontitis group was significantly higher than that in the control group, the difference was significant (P<0.05).@*CONCLUSIONS@#The TNF-α, PGE2 expression of the rat periodontal tissue in the periodontitis group was significantly higher than the control group.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Periodontitis
/
Periodontium
/
Immunohistochemistry
/
Dinoprostone
/
Chemistry
/
Tumor Necrosis Factor-alpha
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Rats, Wistar
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Disease Models, Animal
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Metabolism
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2014
Type:
Article