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HIV-negative plasmablastic lymphoma: report of 8 cases and a comprehensive review of 394 published cases
Blood Research ; : 49-56, 2020.
Article in English | WPRIM | ID: wpr-820803
ABSTRACT

BACKGROUND:

Human immunodeficiency virus (HIV)-negative plasmablastic lymphoma (PBL) is a rare entity of diffuse large B-cell lymphoma (DLBCL). The clinicopathological features of and optimal treatment for HIV-negative PBL remain largely unknown.

METHODS:

To gain insight into this distinct lymphoma, we summarized the clinicopathologic characteristics of 8 unpublished HIV-negative PBLs and performed a comprehensive review of 394 published cases.

RESULTS:

Of the 8 unpublished PBLs, the median patient age was 53.0 years. Four patients presented with stage IV disease. All 8 patients showed a plasma cell-like immunophenotype. Of the six patients who received anthracycline-based chemotherapy, including two who received bortezomib, three patients achieved a continuous complete response, two patients died due to disease progression, and one patient was lost to follow-up. The other two patients achieved continuous complete response after receiving chemotherapy combined with radiotherapy and surgery. Of the 402 patients, the majority were male, with a mean age of 58.0 years. EBV infection was detected in 55.7% of the patients. The median survival times of the patients who received CHOP or CHOP-like regimens and intensive regimens were not reached and 23.0 months, respectively, and the intensive regimen did not improve the survival outcome (P=0.981). Multivariate analysis showed that EBER remained the only independent factor affecting overall survival (OS).

CONCLUSION:

HIV-negative PBL is a distinct entity with a predilection for elderly and immunosuppressed individuals. Intensive chemotherapy had no apparent survival benefits over the CHOP regimen in terms of OS; the prognosis of this disease is poor with current chemotherapy methods, and treatment remains a challenge.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasma / Prognosis / Radiotherapy / Multivariate Analysis / Lymphoma, B-Cell / HIV / Disease Progression / Epstein-Barr Virus Infections / Drug Therapy / Lost to Follow-Up Type of study: Prognostic study Limits: Aged / Humans / Male Language: English Journal: Blood Research Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasma / Prognosis / Radiotherapy / Multivariate Analysis / Lymphoma, B-Cell / HIV / Disease Progression / Epstein-Barr Virus Infections / Drug Therapy / Lost to Follow-Up Type of study: Prognostic study Limits: Aged / Humans / Male Language: English Journal: Blood Research Year: 2020 Type: Article