Research progress of extracellular high mobility group box 1 in common ophthalmic diseases / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
;
(12): 813-817, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-820897
ABSTRACT
@#High mobility group box 1(HMGB1), which belongs to a high mobility group box that known for high mobility in electrophoresis, has been researching most intensively. Recently, researches have revealed that extracellular HMGB1, as a damage-associated molecular pattern(DAMP), is involved in the pathophysiology of tissue damage repairin a variety of common ocular diseases, namely, dry eye, keratopathy, glaucoma, uveitis, diabetic retinopathy, and age-related macular degeneration, thereby negatively affecting the healing of the disease. Silencing the function of extracellular HMGB1 is expected to be a new way for these ophthalmic diseases. This thesis reviews the research progress of extracellular HMGB1 in common ophthalmic diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Eye Science
Year:
2020
Type:
Article
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