Correlation analysis of single nucleotide polymorphisms in autophage-related 5 ( ATG[STHZ]5[STBZ] ) gene promoter with acute myocardial infarction / 临床检验杂志

ABSTRACT

Objective@#To investigate the correlation of single nucleotide polymorphisms (SNPs) in autophage-related 5 ( ATG5 ) gene promoter with acute myocardial infarction (AMI). @*Methods@#The SNPs of ATG5 gene promoter were detected by polymerase chain reaction (PCR) and Sanger sequencing. The typing and correlation of SNPs in 378 AMI patients and 374 healthy controls were analyzed by Chi-square test, Logistic regression analysis and haplotype analysis. @*Results@#Two SNPs of ATG5 gene promoter, rs506027 (OR=1.4, 95% CI \[0.6-3.0\], P=0.411) and rs510432 (OR=1.6, 95% CI \[0.7-3.4\], P=0.275), were found. They didn′t increase the susceptibility of AMI, and the haplotype associated with AMI was not found in the two SNPs. @*Conclusion@#The polymorphism of ATG5 gene promoter isn′t associated with the susceptibility of AMI.