Association analysis of ORMDL3 gene polymorphism with bronchial asthma of Uygur people in Urumqi region / 临床检验杂志

ABSTRACT

Objective@#To investigate the association of ORMDL3 gene polymorphism with the risk of bronchial asthma of Uygur people in Urumqi region. @*Methods@#Ten single nucleotide polymorphism (SNP) loci of ORMDL3 gene in 93 Uygur patients with bronchial asthma and 100 healthy controls were genotyped by the multiplex SNP (SNaPshot) technique, and the association of different genotypes and alleles with the risk of asthma of Uygur people was analyzed. @*Results@#There were significant differences in genotype and allele frequencies of rs7216389 and rs12603332 loci of ORMDL3 gene between asthma patients and healthy controls (P＜0.05). The detection data of SNP loci of ORMDL3 gene were all in accordance with Hardy-Weiberg law (P＞0.05). @*Conclusion@#The polymorphism of ORMDL3 gene is directly associated with the risk of asthma in Uygur people, and the rs7216389 and rs12603332 loci of ORMDL3 gene may be the susceptible sites of bronchial asthma in Uygur people.