Cost-effectiveness Analysis of Glecaprevir/Pibrentasvir versus Elbasvir/Grazoprevir in Chronic Hepatitis C Genotype 1b Treatment-naive Patients without Cirrhosis / 中国药房
China Pharmacy
;
(12): 1113-1118, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-821503
ABSTRACT
OBJECTIVE:To evalua te the economics of glecaprevir/pibrentasvir (G/P)versus elbasvir/grazoprevir (EBR/GZR) in chronic hepatitis C genotype 1b(GT1b)treatment-naive patients without cirrhosis ,and to provide evidence support for medical and health decision-making. METHODS :Under assuming the bid price of G/P and EBR/GZR therapy schemes before medical insurance negotiation was adopted (scenario 1)and assuming that the price of EBR/GZR was reduced by 85% and the price of G/P was reduced by 80%(scenario 2),Markov model was developed to simulate the lifetime cost and health outcomes progress of 10 000 untreated chronic hepatitis C GT 1b treatment-naive patients without cirrhosis and calculate incremental cost-effectiveness ratio(ICER). Single factor sensitivity analysis and probability sensitivity analysis were conducted to verify the results. The highest price(price reduction ratio )of G/P scheme was analyzed with cost-effectiveness advantage ,when other parametes kept stable under scenario 2. RESULTS :Under 2 kinds of scenarios ,compared with EBR/GZR scheme ,G/P scheme had higher cost (scenario 1:68 800 yuan vs. 62 338 yuan;scenario 2:13 760 yuan vs. 11 490 yuan)and healty utility (scenario 1:14.97 QALY vs. 14.90 QALY;scenario 2:14.97 QALY vs. 14.90 QALY),and ICER value of G/P was lower than willingness-to-pay threshold (scenario 1:92 314 yuan/QALY;scenario 2:32 428 yuan/QALY). The change of most parameters in single factor sensitivity analysis didn ’t influence the results of base-case analysis ,and the findings from the base-case analysis were confirmed by probability sensitivity analyses. The price of G/P scheme needed to be reduced by at least 62% to realize cost-effective advantage. CONCLUSIONS : Under the set price scenario ,G/P scheme has cost-effectiveness advantages than EBR/GZR scheme in chronic hepatitis C GT 1b treatment-naive patients without cirrhosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Health economic evaluation
/
Prognostic study
Language:
Chinese
Journal:
China Pharmacy
Year:
2020
Type:
Article
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