Association between nonalcoholic fatty liver disease and gut microbiota based on the theory of gut-liver axis / 临床肝胆病杂志

ABSTRACT

Nonalcoholic fatty liver disease (NAFLD) has become the most important chronic liver disease and is recognized as the hepatic manifestation of metabolic syndrome, which may progress to liver fibrosis, liver cirrhosis, and even hepatocellular carcinoma in the advanced stage. Gut microbiota, as important symbiotic organisms in the human body, affects metabolic function and may be closely associated with NAFLD, and the theory of gut-liver axis provides a theoretical basis for understanding that intestinal dysbacteriosis may cause liver pathological changes. This article explores the association between NAFLD and gut microbiota, so as to lay a theoretical foundation for the future research on the therapy for NAFLD targeting gut microbiota.