The relationship between vitamin D receptor gene polymorphism and retinopathy in type 2 diabetic patients / 国际眼科杂志(Guoji Yanke Zazhi)

ABSTRACT

@#AIM: To investigate the relationship between vitamin D receptor gene polymorphism and retinopathy in patients with type 2 diabetes mellitus. <p>METHODS: Totally 198 T2DM patients admitted to our hospital from February 2018 to January 2019 were selected as the study objects and divided into DR group(<i>n</i>=108)and non DR group(<i>n</i>=90). The polymorphisms of rs1544410 and rs2228570 were detected by PCR restriction fragment length polymorphism. The relationship between rs1544410, rs2228570 gene polymorphism and retinopathy in type 2 diabetic patients was analyzed by unconditional Logistic regression. <p>RESULTS: The frequencies of T allele at rs1544410 and A allele at rs2228570 in DR group were significantly higher than those in non DR group(<i>P</i><0.05). There were 130 cases of CC genotype, 52 cases of CT genotype, 16 cases of TT genotype, and there were statistical differences between CC genotype and CT+TT genotype(<i>P</i><0.05); 121 cases of GG genotype, 59 cases of GA genotype,18 cases of AA genotype, and there were statistical differences between GG genotype and GA+AA genotype(<i>P</i><0.05); CT+TT genotype of BSMI gene and GA+AA genotype of FokI gene were risk factors of DR(<i>P</i><0.05). <p>CONCLUSION: The polymorphism of VDR gene BSMI and FokI is significantly related to type 2 diabetic retinopathy, which may be the susceptible gene locus of type 2 diabetic retinopathy.