Extrahepatic Manifestations of Primary Biliary Cholangitis
Gut and Liver
; : 771-780, 2017.
Article
in En
| WPRIM
| ID: wpr-82311
Responsible library:
WPRO
ABSTRACT
Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by progressive destruction of the intrahepatic bile ducts, leading to cholestasis. PBC is known to have both hepatic and extrahepatic manifestations. Extrahepatic manifestations are seen in up to 73% of patients with PBC, with the most common being Sjogren’s syndrome, thyroid dysfunction and systemic sclerosis. It is thought that patients with PBC are at increased risk of developing these extrahepatic manifestations, almost all of which are autoimmune, because patients with autoimmune disease are at higher risk of developing another autoimmune condition. Due to the high prevalence of extrahepatic diseases in patients with PBC, it is important to complete a thorough medical history at the time of diagnosis. Prompt recognition of extrahepatic disease can lead to improved patient outcomes and quality of life. The following review summarizes the most common extrahepatic conditions associated with PBC.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Quality of Life
/
Scleroderma, Systemic
/
Autoimmune Diseases
/
Thyroid Gland
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Bile Ducts, Intrahepatic
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Cholangitis
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Cholestasis
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Prevalence
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Diagnosis
/
Liver Diseases
Type of study:
Diagnostic_studies
/
Prevalence_studies
Limits:
Humans
Language:
En
Journal:
Gut and Liver
Year:
2017
Type:
Article