Sessile Serrated Adenomas: How to Detect, Characterize and Resect
Gut and Liver
;
: 747-760, 2017.
Article
in English
| WPRIM
| ID: wpr-82313
ABSTRACT
Serrated polyps are important contributors to the burden of colorectal cancers (CRC). These lesions were once considered to have no malignant potential, but currently up to 30% of all CRC are recognized to arise from the serrated neoplasia pathway. The primary premalignant lesions are sessile serrated adenomas/polyps (SSA/Ps), although traditional serrated adenomas are relatively uncommon. Compared to conventional adenomas, SSA/Ps are morphologically subtle with indistinct borders, may be difficult to detect endoscopically, are more prevalent than previously thought, are associated with synchronous and metachronous advanced neoplasia, and have a higher risk of incomplete resection. Although many lesions remain “dormant,” progressive disease is associated with the development of dysplasia and more rapid progression to CRC. As a result, SSA/Ps are strongly implicated in the development of interval cancers. These factors represent unique challenges that require a meticulous approach to their management. In this review, we summarize the contemporary literature on the characterization, detection and resection of SSA/Ps.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polyps
/
Colorectal Neoplasms
/
Adenoma
Language:
English
Journal:
Gut and Liver
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS