Clinical characteristics and management of asthma and COPD overlap syndrome in Nanchong / 公共卫生与预防医学

ABSTRACT

Objective To investigate the clinical characteristics and management of asthma and COPD overlap syndrome in Nanchong area. Methods The data of respiratory medicine patients in Nanchong area from October 2017 to November 2019 were collected. Patients who met the criteria were classified as asthma and COPD (ACOS) group (104 cases), asthma (BA) group (120 cases), and COPD group (116 cases). The clinical data of the three groups were compared and their general data and clinical characteristics were analyzed. Results The BA group had the highest proportion of patients with smoking history (92.50%), and had the least amount of smoking (P<0.05). The lung function indexes of ACOS group and COPD group were significantly lower than those of BA group (P<0.05). After inhaling bronchodilators, the variation rate of forced expiratory volume in the first second of the ACOS group was significantly higher than that of the COPD group (P<0.05). Patients in the COPD group had the lowest levels of immunoglobulin E (sIgE) and FeNO, while patients in the ACOS group had the highest level of EOS (P<0.05). Conclusion Compared with BA patients, ACOS patients were older and had a lower proportion of smoking but higher smoking quantity, and their lung function was significantly worse. Compared with COPD patients, ACOS patients had a higher proportion of smoking but lower smoking quantity, with better lung diffusion function, and high airway inflammation. The peripheral blood eosinophils in ACOS patients were specifically increased, which can be used as a reference for clinical diagnosis.