Adcance in radiation-induced skin injury under different radiotherapy and chemotherapy regimens / 医学研究生学报

ABSTRACT

Radiation skin injury is a common and severe adverse event of radiotherapy in patients with head and neck cancer or nasopharyngeal carcinoma, which not only limits the radiation dose of the tumor, but also seriously affects the follow-up treatment and quality of life of the patients. It has become a bottleneck to improve the curative effect of tumor. The occurrence of radiation skin injury is a complex process of the interaction of many factors, which is closely related to the patient's own factors, radiotherapy technology, radiotherapy dose segmentation scheme and the combined regimens of radiotherapy and chemotherapy. Different regimens of radiotherapy and chemotherapy with drugs have effects on the occurrence and development of acute skin injury. There is still a lack of effective prevention and treatment of radiation-induced skin injury. Therefore, it is of great significance to explore its mechanism and radiation skin damage caused by different radiotherapy and chemotherapy regimens. This paper mainly reviews the combined application of concurrent chemoradiotherapy, induction and adjuvant chemotherapy to aggravate skin injury and its related mechanisms.