Research advances of EDIL3 in tumor / 国际肿瘤学杂志

ABSTRACT

Epidermal growth factor (EGF)-like repeat and discoidin Ⅰ-like domain 3 (EDIL3)is a extracellular matrix protein that produced and secreted by endothelial cells and plays important roles in embry-onic development,angiogenesis,and limit inflammation. Several recent studies indicate that EDIL3 is aberrant-ly expressed in pancreatic cancer,liver cancer,colorectal cancer,lung cancer and breast cancer,which is as-sociated with cell proliferation,apoptosis,invasion,metastasis,and angiogenesis. EDIL3 is widely participated in the regulating tumor initiation,progression and metastasis,and its abnormal expression is expected to provide a new method for diagnosis and therapy of cancers.