Research progress in animal model of Perthes disease / 中华实用儿科临床杂志

ABSTRACT

Perthes disease is the ischemic necrosis of femoral head in children.It was also called osteochondrositis of femoral head in children,aseptic necrosis of femoral head,avascular necrosis of femoral head,etc.,which reflected people's understanding of this disease in different periods.The disease has a certain tendency of self-healing.The femoral head deformity left behind by some of the children may lead to the hip joint weight-bearing and mobility dysfunction,or even disability and deformity,and the clinical effect is worrying.Despite more than 100 years of research,the etiology and pathogenesis are still unclear,mainly due to the lack of ideal animal models for the corresponding research.Over the years,many efforts and attempts have been made by scholars.At present,the recent studies on animal model of Perthes disease have been reviewed in order to provide references for children's orthopaedic doctors to further understand this disease.