Advances in research of signaling pathway-related microRNA in osteosarcoma / 实用肿瘤学杂志

ABSTRACT

Osteosarcoma is a relatively common malignant tumor originating from bone tissue,which occurs in children and adolescents. In recent years,the role of microRNA in the development of bone tumors has become a hot topic. Numerous studies have shown that microRNA can affect the expression of target genes through MAPK/ERK,PI3K/AKT,Wnt/β-catenin and other signaling pathways,thereby regulating the biological functions such as proliferation,differentiation and invasion of tumor cells,and the develop-ment of osteosarcoma. MicroRNA is closely related to the development,clinical treatment and prognosis of osteosarcoma.