Relationship between ambulatory blood pressure parameters and left ventricular hypertrophy in patients with essential hypertension／ / 心血管康复医学杂志

ABSTRACT

To relationship between ambulatory 24h blood pressure parameters and left ventricular hyper‐trophy in patients with essential hypertension .Methods:A total of 106 EH patients (EH group) and 50 healthy vol‐unteers (healthy control group) were selected from our hospital ,and all subjects received 24h ambulatory blood pres‐sure monitoring .According to clinical condition ,EH patients were divided into stage I group (n＝43) ,stage II and III group (n＝63) ;according to left ventricular mass index (LVMI) ,they were divided into no left ventricular hy‐pertrophy (NLVH) group (n＝ 56 ) and LVH group (n＝ 50 ) ,blood pressure load and blood pressure variability (BPV) indexes were compared among above groups .Results: Compared with stage I group ,there were significant rise in percentages of 24hSBP load ≥ 25% (20. 93% vs.77.78%) , 24h mean SBP (24hmSBP )≥ 130mmHg (30.23% vs.73.02%) and 24hSBP standard deviation (24hSSD)≥11.9 (16. 27% vs.82. 54%) in stage II and III group , P＝0. 001 all.Compared with healthy control group ,there were significant rise in daytime mean DBP (dm‐DBP) ,nighttime mean DBP (nmDBP) ,24hSBP load ,24hDBP load and nighttime SBP (nSBP) load in NLVH group and LVH group , P＜0.05 or ＜0.01 ;compared with NLVH group ,there were significant rise in 24hmSBP ,night‐time mean SBP (nmSBP) ,daytime SBP (dSBP) load ,24hSSD and daytime SBP standard deviation (dSSD) in LVH group , P＜ 0.05 or ＜ 0.01 ; compared with stage I group , there were significant rise in 24hmSBP , nmSBP , 24hSBPload ,nSBP load ,24hSSD ,dSSD and nighttime SBP standard deviation (nSSD) in stage II and III group , P＜0.05 or ＜0.01. Conclusion: The 24h blood pressure parameters is closely associated with left ventricular hyper‐trophy in patients with essential hypertension .Reducing 24h ambulatory blood pressure load and variability can re‐duce risk of left ventricular hypertrophy .