Influence of pitavastatin on insulin resistance in CHD + NAFLD patients with normal liver function and its safety analysis／ / 心血管康复医学杂志

ABSTRACT

To explore influence of pitavastatin on insulin resistance (IR ) in patients with coronary heart disease (CHD) complicated non‐alcoholic fatty liver disease (NAFLD ) and normal liver function and its safety . Methods:A total of 205 CHD + NAFLD patients from our hospital were selected as NAFLD group ,another 70 CHD patients without NAFLD were regarded as non‐NAFLD group .According to NAFLD severity ,NAFLD group was further divided into NAFLD mild group (n＝87) ,moderate group (n＝64) and severe group (n＝54).All pa‐tients received pitavastatin based on routine treatment for 12 weeks .Homeostasis model‐insulin resistance index (HOMA‐IR) before and after treatment ,and incidence rate of severe liver damage were observed and compared a‐mong four groups .Results:Compared with before treatment ,there was significant reduction in HOMA‐IR in four groups after treatment , P＝0. 001 all.Compared with non‐NAFLD group before treatment ,there was significant rise in HOMA‐IR [(3.08 ± 0. 35) vs.(3. 65 ± 0.42) vs.(4. 12 ± 0. 31) ,(4.21 ± 0.47)] in mild ,moderate and severe group ,and those of moderate and severe group were significantly higher than that of mild group , P＝0. 001 all ;af‐ter treatment ,compared with non‐NAFLD group , the HOMA‐IR of mild group was no significant difference ,but compared with non‐NAFLD group and mild group there was significant rise in HOMA‐IR [ (2. 54 ± 0.38) ,(2. 61 ± 0.47) vs.(2.97 ± 0. 35 ) ,(3. 08 ± 0.44)] in moderate and severe group , P＝ 0.001 all.There was no significant difference in incidence rate of severe liver damage among four groups , P＝0. 872. Conclusion:Pitavastatin can sig‐nificantly reduce HOMA‐IR with good safety in CHD + NAFLD patients with normal liver function ,which is worth extending .