Your browser doesn't support javascript.
loading
Impact of levosimendan on cardiac function ,plasma BNP and serum cytokine levels in AHF patients/ / 心血管康复医学杂志
Chinese Journal of cardiovascular Rehabilitation Medicine ; (6): 63-67, 2019.
Article in Chinese | WPRIM | ID: wpr-823872
ABSTRACT
To observe therapeutic effect of levosimendan on acute heart failure (AHF) and its impact on cardiac function ,levels of brain natriuretic peptide (BNP) ,high sensitive C reactive protein (hsCRP) ,tumor necro‐sis factor (TNF)‐α and interleukin (IL)‐6.

Methods:

A total of 148 AHF patients treated in our hospital from Jan 2016 to Jan 2018 were randomly and equally divided into dobutamine group and levosimendan group ,both groups re‐ceived corresponding medication based on routine treatment for 21d.Cardiac function ,levels of plasma BNP ,serum hsCRP ,TNF‐α and IL‐6 ,6min walking distance (6MWD) before and after treatment ,total effective rate and inci‐dence of adverse reactions were observed and compared between two groups .

Results:

Total effective rate of levosi‐mendan group was significantly higher than that of dobutamine group (83. 78% vs.68.92%) , P=0.033. Compared with dobutamine group after treatment , there were significant rise in LVEF [ (49. 98 ± 3. 68 )% vs.(52.17 ± 3.82)%] ,stroke volume [SV ,(67. 52 ± 5. 79) ml vs.(69. 48 ± 5. 83) ml] and 6MWD [ (328.46 ± 31.62) m vs. (396.75 ± 31.89) m] ,and significant reductions in left ventricular end systolic dimension [ (54. 12 ± 8.64) mm vs. (51.31 ± 8.26) mm] ,left ventricular end diastolic dimension [(65.25 ± 8. 86) mm vs.(62.14 ± 8.57) mm] ,levels of plasma BNP [ (572.59 ± 89. 62) mg/ml vs .(351.78 ± 81. 41) mg/ml] ,serum TNF‐α [ (24. 68 ± 5.83) ng/L vs. (21.05 ± 5. 39) ng/L] ,IL‐6 [(21.36 ± 4. 51) ng/L vs.(18.29 ± 4.34) ng/L] and hsCRP [(4. 89 ± 2. 15) ng/L vs. (3. 06 ± 1.47) ng/L] in levosimendan group , P<0. 05 or <0. 01. There was no significant difference in incidence rate of adverse reactions during treatment between two groups , P=0.690.

Conclusion:

Compared with dobutamine , levosimendan possesses more significant therapeutic effect on AHF .It can more significantly improve cardiac func‐tion ,exercise capacity and reduce cytokine levels in these patients .

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of cardiovascular Rehabilitation Medicine Year: 2019 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of cardiovascular Rehabilitation Medicine Year: 2019 Type: Article