Influencing factors of cognitive dysfunction in patients with ischemic white matter lesions and clinical intervention strategy for it／ / 心血管康复医学杂志

ABSTRACT

To explore influencing factors of cognitive dysfunction in patients with ischemic white matter lesions (IWML) and clinical intervention strategy for it .Methods:A total of 98 IWML patients were divided into no cognitive dysfunction group (n＝52) and cognitive dysfunction group (n＝46) according to presence of cognitive dysfunction and no .Age ,gender ,years of education ,levels of total cholesterol (TC) ,low density lipoprotein cho‐lesterol (LDL‐C) ,IWML class and lesion type were compared between two groups .Results: Compared with no cog‐nitive dysfunction group ,there were significant rise in age [ (64. 12 ± 4. 71) years vs.(70. 06 ± 4.82) years] ,serum LDL‐C level [ (2.54 ± 0.67 ) mmol／L vs.(2.89 ± 0. 85 ) mmol／L ] , percentages of hypertension (26.92% vs. 63. 04%) ,diabetes mellitus (23.08% vs.54.35%) and IWML class 3 (3.85% vs.31.43%) ,and significant reduc‐tion in percentage of IWML class 1 (59.62% vs.19. 57%) and years of education [ (9. 97 ± 2.82) years vs .(8. 12 ± 2.36) years] in cognitive dysfunction group , P＜0.05 or ＜0.01 ;multi‐factor Logistic regression analysis indicated that age and IWML class were independent risk factors for cognitive dysfunction (OR＝1.142 , 4.752 ; P＝0.007 , 0.012) ,while years of education was its independent protective factor in IWML patients (OR ＝ 0.514 ; P＝0.020 ).Conclusion: Cognitive dysfunction is closely related with age ,years of education and IWML class in IWML patients .Physicians should take targeted measures in time to prevent occurrence of cognitive dysfunction according to patient’ s comprehensive condition .