Advance in biomarkers of neuromyelitis optica / 中华实验眼科杂志
Chinese Journal of Experimental Ophthalmology
;
(12): 973-976, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-823903
ABSTRACT
Neuromyelitis optica (NMO) is an autoimmune,demyelinating disease of the central nervous system manifesting with optic neuritis and longitudinally extensive transverse myelitis.Aquaporin-4 (AQP4)-IgG is currently regarded as a specific biomarker of NMO.Nevertheless,AQP4-IgG seronegativity in 10%-25% of NMO patients suggests that there are several other factors involved in NMO immunopathogenesis.In this article,we reviewed current knowledge about biomarkers of NMO from AQP4,myelin-oligodendrocyte glycoprotein,AQP1 and glial fibrillary acidic protein,providing a new insight in the diagnosis of NMO.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Experimental Ophthalmology
Year:
2019
Type:
Article
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