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Raspberry ketone attenuates high-fat diet-induced obesity by improving metabolic homeostasis in rats
Asian Pacific Journal of Tropical Biomedicine ; (12): 18-22, 2020.
Article in Chinese | WPRIM | ID: wpr-823912
ABSTRACT

Objective:

To investigate the molecular mechanisms of the anti-obese effect of raspberry ketone against high-fat diet fed rats.

Methods:

Fifty adult male rats were randomly assigned to receive a standard diet, a high fat diet, and the high-fat diet and 0.5%, 1%or 2% raspberry ketone. Body weight, biochemical parameters and gene expression of CCAAT enhancer-binding protein (C/EBP)-δ, fatty acid synthase (FAS), acetyl CoA carboxylase (ACC), peroxisome proliferator-activated receptor alpha (PPAR-α), hormone-sensitive lipase (HSL) and hepatic carnitine palmitoyltransferase 1 A (CPT1A) were investigated.

Results:

Body weight, blood glucose, insulin, total lipids, triacylglycerols, total cholesterol and low-density lipoprotein cholesterol were increased in high-fat diet fed rats. These high fat diet-induced changes were attenuated by treatment with raspberry ketone. High-density lipoprotein cholesterol was decreased in high-fat diet fed rats but increased in rats treated with raspberry ketone. Molecular investigations showed induction of gene expression of C/EBP-δ, FAS, ACC, CPT1A and inhibition of gene expression of PPAR-α and HSL in high-fat diet fed rats as compared with control. Raspberry ketone treament reversed these changes except CPT1A.

Conclusions:

Raspberry ketone can prevent obesity induced by a high-fat diet in rats by induction of the expression of enzymes, controlling lipolysis and fatty acids β oxidation as well as inhibition of gene expressions of adipogenic factors.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Asian Pacific Journal of Tropical Biomedicine Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Asian Pacific Journal of Tropical Biomedicine Year: 2020 Type: Article