Clinical study on the relationship between hyperthyroidism and vascular endothelial injury / 中华地方病学杂志

ABSTRACT

Objective To observe the relationship between hyperthyroidism and vascular endothelial injury.Methods From 2016 to 2017,data of 60 patients with simple hyperthyroidism,autoimmune thyroid disease,cardiovascular and cerebrovascular diseases were collected from the Second Affiliated Hospital of Harbin Medical University.And 60 healthy subjects were enrolled in the same period as a healthycontrol group.The enzyme-linked immunosorbent assay (ELISA) was used to detect the content of vascular endothelial injury markers (vWF),thrombomodulin (TM),endothelin-1 (ET-1),P-selectin in serum of all subjects,as well as the serum thyroid stimulating hormone (TSH),free triiodothyronine (FT3),free thyroxine (FT4),anti-thyroglobulin antibody (TgAb),and anti-thyroid peroxidase antibody (TPOAb) in patients with cardiovascular and cerebrovascular diseases levels.The correlation analysis of vascular endothelial injury in the simple hyperthyroidism group,autoimmune thyroid disease group,cardiovascular and cerebrovascular diseases group and healthy control group was conducted.Results There were statistically significant differences between the he althy control group,the simple hyperthyroidism group,the autoimmune thyroid disease group and the cardiovascular and cerebrovascular diseases group in the serum levels of vWF,TM,ET-1 and P-selectin,respectively (F =6.56,9.19,7.88,12.45,P ＜ 0.05),and the simple hyperthyroidism group,autoimmune thyroid disease group,cardiovascular and cerebrovascular diseases group were significantly higher than the healthy control group (P ＜ 0.05).Correlation analysis showed that the vascular endothelial injury in the patients with simple hyperthyroidism,autoimmune thyroid disease,and cardiovascular and cerebrovascular diseases groups was statistically significantly different compared with the healthy control group,respectively (x2 =5.08,5.08,8.16,P ＜ 0.05);the risk of vascular endothelial injury in each diseased group was 2.37,2.37,and 3.07 times higher than that of the healthy control group,respectively.The abnormal rates of TSH,FT3,FT4,TgAb and TPOAb in patients with cardiovascular and cerebrovascular diseases were 18.33％ (11/60),15.00％ (9/60),15.00％ (9/60),10.00％ (6/60) and 11.7％ (7/60),respectively.Conclusion Simple hyperthyroidism and autoimmune thyroid disease are risk factors of vascular endothelial injury.