Clinical significance of aluminum phosphate gel in the prevention of gastrointestinal reactions caused by erythromycin in the treatment of Mycoplasma pneumonia / 中国基层医药

ABSTRACT

Objective To evaluate the clinical significance of aluminum phosphate gel in the early preven-tion of gastrointestinal reactions caused by erythromycin , in order to obtain better clinical treatment for children. Methods The clinical data of 110 children with Mycoplasma pneumonia from January 1,2015 to December 31,2016 in the pediatric ward of Anhui Provincial Hospital were collected.According to the treatment methods ,the patients were divided into the observation group (60 cases) and the control group (50 cases).The observation group was mainly treated with erythromycin combined with aluminum phosphate gel ,some of which were given cephalosporin anti-infection,montelustra sodium to reduce airway hyperreaction ,hormone antiasthmatic,atomization inhalation and other supportive symptomatic treatment.The control group was mainly treated with erythromycin ,some of which were given cephalosporin anti-infection,montelustra sodium to reduce airway hyperreaction ,hormone antiasthmatic,atomi-zation inhalation and other supportive symptomatic treatment.The age,body weight,pre-hospital course,white blood cell count(WBC),CRP,alanine aminotransferase (ALT),creatinine(Cr),urea nitrogen (BUN),length of stay,sex, montruster sodium granules ,atomization,antibiotics, hormone use and gastrointestinal adverse reactions ( abdominal pain,vomiting, nausea, diarrhea, inappetence ) were compared between the two groups.Results A total of 110 children were selected,60 cases in the treatment groups ,including 38 males and 22 females,and the average age of children was (6.21 ± 2.26 ) years old.In the control group, there were 50 cases, including 23 males and 27 females,with an average age of (6.07 ±2.61)years.The age,weight,pre-hospital course,WBC,CRP,ALT,Cr, BUN,days of hospitalization ,etc.between the two groups had no statistically significant differences ( all P＞0.05). There were no statistically signifiant differences between the two groups in terms of sex ,montruster sodium particles, atomization,antibiotics,hormone use,etc.( all P＞0.05).The differences of abdominal pain ,vomiting,nausea and diarrhea between the two groups were not statistically significant (all P＞0.05).However,the difference of inappe-tence between the two groups was statistically significant ( P ＜0.05).The incidence rate of gastrointestinal side effects(abdominal pain,vomiting,nausea,diarrhea,inappetence ) of the observation group was 18.3 %(11／60 ), which of the control group was 48.0%(24／50),the difference was statistically significant between the two groups (χ2 ＝11.064,P＜0.05).Conclusion Aluminum phosphate gel can prevent gastrointestinal reactions induced by erythromycin in the treatment of Mycoplasma pneumonia ,so that children get better treatment.