Effect of laparoscopic myomectomy on serum sex hormones, inflammatory factors and immune function in patients with uterine fibroids / 中国基层医药

ABSTRACT

Objective To investigate the effect of laparoscopic myomectomy on serum sex hormones,inflammatory factors and immune function in patients with uterinefibroids.Methods FromJanuary2014 toMay2017,100patients with uterine fibroids who were treated in the People's Hospital of Taigu County were selected .The patients were divided into control group and observation group according to the random number table method ,with 50 cases in each group .The control group was treated with conventional myomectomy , while the observation group was treated with laparoscopic myomectomy .The serum levels of follicle stimulating hormone ( FSH ) , luteinizing hormone ( LH ) , estradiol ( E2 ) , interleukin 6(IL-6),interleukin 10(IL -10),tumor necrosis factor -α(TNF -α) and immune function were compared before and after operation.Results The serum levels of FSH,LH,IL -10,CD3+,CD4+,CD8+ in the observation group after operation were (7.81 ±2.29) IU/L,(10.52 ±2.73) IU/L,(12.64 ±2.18) ng/L,(52.67 ± 4.87)％,(31.56 ±3.82)％,(22.55 ±2.16)％,respectively,which were higher than those in the control group [(7.36 ±2.11)IU/L,(9.86 ±2.48) IU/L,(8.64 ±2.03) ng/L,(46.32 ±4.64)％,(27.62 ±3.78)％,(16.87 ± 2.14)％],the serum levels of E2,IL-6,TNF-αin the observation group after operation were (65.56 ±5.45)ng/L, (13.67 ±3.56) ng/L,(23.58 ±4.05) ng/L,which were lower than those in the control group [(70.64 ± 5.81)ng/L,(30.57 ±4.11)ng/L,(27.56 ±4.21)ng/L],the differences were statistically significant (t=2.542, 2.589,9.495,6.675,5.184,13.209,4.509,21.977,4.817,all P <0.05).Conclusion Compared with the traditional laparotomy,laparoscopic myomectomy can improve the levels of FSH ,LH and E2 in patients with uterine fibroids,relieve postoperative inflammatory response ,and improve the immune function of patients .