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Expression and clinical significance of lysophosphatidic acid receptor 5 protein in breast cancer / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy ; (12): 213-217, 2020.
Article in Chinese | WPRIM | ID: wpr-824169
ABSTRACT
Objective To investigate the expression and clinical significance of lysophosphatidic acid receptor 5 (LPA5) protein in breast cancer tissues.Methods The specimens of breast cancer tissues and adjacent tissues of 80 breast cancer patients from January 2015 to December 2016 in the First People's Hospital of Yongkang were selected in the study.The expression of LPA5 in breast cancer tissues and adjacent tissues was determined by immunohisto-chemistry.The clinical case characteristics of patients were collected.Results The positive expression rate of LPA5 in breast cancer tissues (72.5%) was higher than that in adjacent tissues (8.75%) (χ2 =67.394,P<0.05).The positive rate of LPA5 in clinical stage Ⅲ-Ⅳ(91.3%) was higher than that in stage Ⅰ-Ⅱ(64.9%)(χ2 =5.725, P<0.05).The positive rate of LPA5 in patients with lymph node metastasis (94.7%) was higher than that in patients without lymph node metastasis (52.4%)(χ2 =17.951,P<0.05).The positive rate of LPA5 in patients with intravascular tumor thrombus ( 92.3%) was higher than that in patients without intravascular tumor thrombus (63.3%)(χ2 =7.580,P<0.05).The expression of LPA5 in breast cancer tissues was not related to age and tumor diameter (P>0.05).There were no significant differences in the positive expression rates of LPA 5 in the breast cancer tissues among luminal type ,human epidermal growth factor receptor 2 (Her2) overexpressing type and triple negative type (P>0.05).The disease-free survival rate(86.3%) and overall survival rate (87.5%) of patients with negative expression of LPA5 in breast cancer tissues were higher than those in breast cancer tissues with positive expression (65.0%,66.3%)(χ2 =4.517,4.328,all P<0.05).Conclusion LPA5 expression is up-regulated in breast cancer tissues,and LPA5 may be involved in the development and progression of breast cancer ,which is closely related to the prognosis of breast cancer.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Primary Medicine and Pharmacy Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Primary Medicine and Pharmacy Year: 2020 Type: Article