Clinical analysis of third-line combination therapy with S-1 plus apatinib for advanced colorectal cancer / 中国肿瘤临床
Chinese Journal of Clinical Oncology
;
(24): 945-948, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-824322
ABSTRACT
Objective:
To investigate the efficacy and toxicity of apatinib combined with S1 as a third-line therapy for advanced colorectal cancer.Methods:
Forty-four patients with adavanced colorectal cancer from Tongji Hospital Cancer Center were enrolled from April 2016 to August 2018. The median follow-up period was 8 months. Data related to efficacy and adverse effects were recorded.Results:
The median progression-free survival (PFS) time was 3.93 months (95%CI 2.72-5.15 months), and the median overall survival (OS) time was 7.77 months (95%CI 5.36-10.18 months). Patients with left hemicolon cancer and rectal cancer group had a longer PFS than patients with right hemicolon cancer group (4.94 months vs . 3.89 months, P=0.024); the OS for left hemicolon cancer and rectal cancer was 12.5 months, the OS for right hemicolon cancer was 7.4 months, P=0.080; gender, previous bevacizumab use and liver metastasis had no statistically significant effect on PFS and OS; the PFS was 4.48 months and 1.10 month, in the patients with ECOG 0-1 and ECOG 2; the OS was 9.67 months and 2.90 month, in these two groups respectively. The major adverse effects of the combination therapy were fatigue (52.3%), hypertension (45%), hand-foot syndrome (22.7%), leukopenia (15.9%), and neutropenia (15.9%), thrombocytopenia (22.7%), elevated transaminase levels (13.6%), diarrhea (15.9%).Conclusions:
The results suggest that the combination of apatinib and S-1 is safe and effective as a third-line treatment for advanced colorectal cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Clinical Oncology
Year:
2019
Type:
Article
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