The value of gadolinium?ethoxybenzyl?diethylenetriamine pentaacetic acid enhanced T1 mapping MRI in the quantitative evaluation of hepatic fibrosis in patients with hepatitis B / 中华放射学杂志

ABSTRACT

Objective To investigate the quantitative evaluation efficiency of gadolinium?ethoxybenzyl?diethylenetriamine pentaacetic acid (Gd?EOB?DTPA) enhanced T1 mapping in staging hepatic fibrosis caused by viral hepatitis B. Methods One hundred and fifty patients with chronic hepatitis B were prospectively enrolled in Shanghai Public Health Clinical Center, Fudan University from August 2016 to August 2018.These patients underwent liver aspiration biopsy were divided into four subgroups S1 (n=38), S2 (n=30), S3 (n=33), S4 (n=49) according to Scheuer?Ludwig scoring system. Non?enhanced and Gd?EOB?DTPA?enhanced MRI were performed in all subjects. Look?Locker sequences were performed to acquire T1 mapping of pre and post?contrast at 20 minutes after Gd?EOB?DTPA administration. The T1 value after 20 minutes of Gd?EOB?DTPA administration (T1 20 min), the reduction rate of T1 value (&Delta;T1 20 min% ), the increase of 1/T1 value (&Delta;R1 20 min% ) were measured and calculated. The one?way ANOVA was applied to compare the difference in T1 20 min, &Delta;T1 20 min%, &Delta;R1 20 min% of various fibrosis stages. ROC curves were used to assess the efficacy of T1 20 min, &Delta;T1 20 min%, &Delta;R1 20 min% for diagnosing≥S2,≥S3,≥S4. P<0.05 was considered to be statistically significant. Results The T1 20 min raised with fibrosis stage increased, &Delta;T1 20 min% and &Delta;R1 20 min% reduced with fibrosis stage increased. Areas under the curves of T1 20 min, &Delta;T1 20 min%, &Delta;R1 20 min% for diagnosing≥S2 were 0.844, 0.905, 0.869; and diagnosing≥S3 were 0.832, 0.907, 0.862; and diagnosing≥S4 were 0.853, 0.897, 0.873, respectively. The diagnostic efficiency of &Delta;T1 20 min% was the best. Conclusion Gd?EOB?DTPA?enhanced T1 mapping could be regarded as a reliable diagnostic tool for the evaluation of hepatic fibrosis caused by viral hepatitis B.