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Therapeutic effect of transcatheter arterial chemoembolization combined with iodine-125 seed strand implantation for treating hepatocellular carcinoma with portal vein tumor thrombus / 中华肝胆外科杂志
Chinese Journal of Hepatobiliary Surgery ; (12): 885-889, 2019.
Article in Chinese | WPRIM | ID: wpr-824502
ABSTRACT
Objective To study the efficacy of combined transcatheter arterial chemoembolization(TACE)with iodine-125 seed implantation in treating hepatocellular carcinoma(HCC)with portal vein tumor thrombus(PVTT).Methods From January 2015 to January 2019,eighty patients with HCC and PVTT who were treated at Affiliated Hospital of Xuzhou Medical University were retrospectively analyzed.A total of 71 patients were male and 9 were female.aged(53.1±9.9)years.The patients included 48 patients(group A)who were treated with TACE alone and 32 patients(group B)with TACE combined with iodine-125 seed implantation.The survival time and disease control rate(DCR)of the intrahepatic lesions and PVTY in the two groups were compared.Results There were 32 patients who were successfully implan-ted with portal vein iodine-125 seed and stents.The DCR of PVTT in group B was significantly better than in group A(90.6% vs.81.3%,P<0.05).The DCR of the intrahepatic lesions in the two groups was 77.1%(group A)and 90.6%(group B).There was no significant difference between the two groups(P>0.05).The survival times of group A and group B were(8.0±0.6)and(16.0±2.1)months,respectively.The median survival times were(7.6±1.0)and(14.8±1.5)months respectively.Group B had significantly better survival time than Group A,(both P<0.05).Univariate and multivariate analysis showed that tumor size was an independent risk factor of prognosis(Regression coemcient0.960,HR0.383,95%CI0.158-0.926,P<0.05).125I treatment was a protective factor of prognosis(Regression coefficient-1.525,HR0.218,95%CI0.100-0.473,P<0.05).Conclusion For patients with HCC and PVTT.compared with TACE alone,TACE combined with iodine-125 seed implantation could safe-ly and effectively control portal vein tumor thrombus,and prolonged patient survival.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study / Risk factors Language: Chinese Journal: Chinese Journal of Hepatobiliary Surgery Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study / Risk factors Language: Chinese Journal: Chinese Journal of Hepatobiliary Surgery Year: 2019 Type: Article