Correlations between systemic immune inflammation index and prognosis of patients with gallbladder carcinoma / 中华肝胆外科杂志

ABSTRACT

Objective To investigate the correlations between the systemic immune inflammatory index(SⅡ)and prognosis of patients with gallbladder cancer.Methods From April 2005 to January 2019,patients with gallbladder cancer underwent surgical treatment in the Department of Hepatobiliary and Pancre-atic Surgery,Affiliated Tumor Hospital of Zhengzhou University were followed up and their SⅡ values were analyzed.The receiver operating characteristic curve(ROC)was used to determine the best clinical bounda-ry value of SⅡ.According to the boundary value,patients were divided into two groupslow SⅡ and high SⅡ.Survival curves were drawn by Kaplan-Meier method.The overall survival time of the two groups was analyzed,and univariate analysis of postoperative survival was performed using log-rank test.Cox regression proportional hazard model was used for multivariate analysis of clinical prognosis.Results A total of 3 12 patients were included,including 120 males and 192 females,aged 30.0 to 86.0(61.5±9.9)years.The best clinical cut off value of preoperative S11 was determined by ROC curve to be 510.42.A total of 312 patients with gallbladder cancer were divided into low SⅡ group(SⅡ≤510.42)and high SⅡ group(SⅡ＞510.42).Kaplan-Meier survival curve was used to analyze the 1,3 and 5-year survival rates of gallbladder cancer patients in low SⅡ group and high SⅡ group after operation.The survival rates were 65.7％.39.6％and 30.2％,and 27.9％,12.O％and 9.6％respectively.The median survival time was 25 months(95％CI16.9-33.1)and 9 months(95％CI8.1-9.9),respectively.The survival rate of gallbladder cancer patients in low SⅡ group was better.There were significant differences of the overall survival rate between the two groups(P＜0.05).Univariate analysis showed that SⅡ＞510.42(HR=0.086,95％C/0.032-0.289)was a risk factor for overall survival of gallbladder cancer patients.Cox multivariate analysis confirmed that preoperative SⅡ(HR=2.649,95％CI1.981-3.543)was an independent risk factor for overall survival of gallbladder cancer patients.Conclusions SⅡ can be used as an independent prognostic factor to predict the prognosis of patients with gallbladder cancer.The higher the preoperative SⅡ,the worse the prognosis of patients with gallbladder cancer.