Effect of p38 mitogen-activated protein kinase inhibitor on liver function and tissue in rats with hepatic hydatidosis / 中华肝胆外科杂志

ABSTRACT

Objective To investigate the effect of p38 mitogen-activated protein kinase(p38 MAPK)inhibitor on liver function and tissue in rats with hepatic hydatidosis.Methods A model of liver echinococcosis was established in 100 female Wistar rats,60 of 100 were,randomly divided into three groups,Control group(0.3 ml normal saline),Low dose group(50 p,mol/L p38MAPK inhibitor SB-202190),High dose group(100 μmol/L SB-202190B).The reagents were given via the hepatic artery 1,3,7,14 and 42 days after the rat model was generated.Rats were sacrificed 42 days after the interven-tion,liver tissue and blood samples were collected for liver function study.Results Alanine aminotrans-ferase levels were(49.58±2.38)U/L,(38.35±1.34)U/L and(30.93±1.51)U/L and aspartic ami-notransferase levels were(67.45±5.14)U/L,(54.86±1.09)U/L and(45.76±1.04)U/L in the Control group,the Low-dose group and High-dose group,showing a decreasing trend,with statistically sig-nificant differences(all P＜0.05).Triglycerides in the Low-dose group were higher than those in Control group and the High-dose group,with statistically significant differences(all P＜0.05).In the Control group,the hepatocytes were severely injured,with almost no normal hepatocytes left,and the normal hepato-cyte boundaries were also disrupted,he normal hepatic lobule was replaced by the pseudolobules.In the Low-dose group,there were more inflammatory cells,and less replacement of normal liver cells by pseud-olobules.High dose group of a small amount of inflammatory cells infiltration,roughly normal liver cells,normal liver cell line is clear,visible central vein of liver cells.Conclusionp38MAPK inhibitor SB-202 190 improved liver function and reduced liver tissue damage in rats with hepatic hydatidosis.