Neurofibriilary tangle-predominant dementia / 中华老年医学杂志

ABSTRACT

Neurofibrillary tangle-predominant dementia (NFTPD)is one type of late-onset dementia,with memory disorders as the main clinical manifestation.The pathological feature is the presence of a large number of neurofibrillary tangle(NFT)in the hippocampus with no or little amyloid deposition in the brain.In recent years,primary age-related tauopathy(PART)has been proposed as a new pathological term,which means that NFT appears in the medial temporal lobe with aging,but no amyloid deposits,and NFTPD is one type of dementia associated with the progression of PART.