Clinicopathologic features and prognosis of young patients with hepatocellular carcinoma / 中华普通外科杂志

ABSTRACT

Objective To study the clinicopathological characteristics and prognosis of young patients with hepatocellular carcinoma (HCC).Methods The clinical data of 1091 HCC patients receiving hepatectomy at Cancer Hospital of Guangxi Medical University from Jan 2006 to Jan 2011 were retrospectively analyzed.Patients were divided into young group (237 cases) and middle and old aged group (854 cases) with the cut-off value of 40 years old.After the data among the correction groups were balanced by tendentious analysis,patients were paired in a 11 ratio.The clinicopathological features and overall survival and recurrence rates after hepatectomy were compared between the two groups.Results Young patients had a higher rate of hepatitis B virus (HBV) infection,better liver function and a higher rate of vascular invasion.The overall survival and disease-free survival of young patients were shorter than those of middle-aged and elderly patients,but the difference was not statistically significant.The 1',3'and 5'year overall survival rates were 80％,58％,53％,and 87％,66％,55％ (x2 =2.895,P =0.089) in the young group and the elderly group,respectively,and the recurrence rates were 53％,80％,88％ and 47％,71％,85％ (x2 =2.886,P--0.089).There was no significant difference in prognosis between the two groups by either subgroup analysis or propensity matching analysis (P ＞ 0.05).Condusion Young HCC patients have characteristically clinicopathological features,and age is not a risk factor determining the prognosis of HCC patients.