Changes and significance of serum soluble programmed death-1 in patients with chronic hepatitis C / 中华微生物学和免疫学杂志
Chinese Journal of Microbiology and Immunology
;
(12): 911-915, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-824808
ABSTRACT
Objective To analyze the changes and significance of serum soluble programmed death-1 (sPD-1) in patients with chronic hepatitis C (CHC) and study its role in the progression of CHC. Methods Serum levels of sPD-1 in CHC patients and healthy controls ( HC) were measured using ELISA and compared. Correlations of serum sPD-1 with peripheral hepatitis C virus ( HCV) RNA, alanine amin-otransferase (ALT), aspartate aminotransferase (AST) and liver fibrosis (indicated by APRI) were ana-lyzed. Results The serum sPD-1 level in the CHC group was significantly higher than that in the HC group (P<0. 05), and positively correlated with peripheral HCV RNA, ALT and AST (P<0. 05). In addition, the serum sPD-1 levels in patients with APRI greater than 1. 2 (indicating severe liver fibrosis) were higher than those in patients without or with mild liver fibrosis (P<0. 05). Conclusions sPD-1 might be involve in the progression of CHC. Measuring serum sPD-1 in CHC patients would assist the prediction of disease progression and help to make the correct diagnosis and appropriate clinical therapy decision.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Microbiology and Immunology
Year:
2019
Type:
Article
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