Current research status and application value of cytokines in drug-induced liver injury / 临床肝胆病杂志

ABSTRACT

Drug-induced liver injury (DILI) refers to liver injury caused by one or more drugs or their metabolites after use. Due to the various types of drugs and large differences between individuals, there are many difficulties in the clinical diagnosis of DILI, and the search for new biomarkers has become a research hotspot. Related studies have shown that cytokines play a key role in DILI, especially idiosyncratic DILI. This article outlines the role of different cytokines in DILI and their value in predicting the severity and evaluating prognosis of DILI. It is pointed out that cytokines have a broad application prospect as biomarkers for DILI.