Research progress in the mechanism of kidney injury caused by SARS-CoV-2 / 公共卫生与预防医学

ABSTRACT

Following the outbreak of Severe Acute Respiratory Syndrome (SARS) in 2003 and the outbreak of Middle East Respiratory Syndrome (MERS) in 2013, a new type of coronavirus (SARS-CoV-2) occurred at the end of 2019, which caused a global pandemic. Many infected people eventually died of multiple organ failure, among which kidney injury was one of the main complications of the virus. Kidney injury is of great significance for the condition judgment and prognosis evaluation of patients with new coronary pneumonia. Renin-Angiotensin-System (RAS), angiotensin converting enzyme 2 (ACE2), cytokine storm, and extracellular matrix metalloproteinase inducer (CD147) are considered to be closely related to the mechanism of kidney injury caused by SARS-CoV-2.