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Attenuation of oxidative stress-induced neuronal cell death by Hydnophytum formicarum Jack
Asian Pacific Journal of Tropical Medicine ; (12): 415-422, 2018.
Article in English | WPRIM | ID: wpr-825865
ABSTRACT

Objective:

To investigate protective effects of Hydnophytum formicarum Jack. (H. formicarum) extracts via regulation of SIRT1-FOXO3a-ADAM10 signaling and antioxidant activity against H

Methods:

Cell viability and apoptosis of neuronal cells pretreated with H. formicarum Jack. extracts under oxidative stress were determined by MTT assay and flow cytometry. The intracellular reactive oxygen species (ROS) was performed using Carboxy-DCFDA assay. Additionally, a profile of protein expressions related to neuroprotection was detected by western blot analysis.

Results:

The plant extracts (methanol and ethyl acetate) elicited protective effects on the neuronal cell death as performed by the MTT assay and by apoptosis analysis via the activation of BCL-2. Both ethyl acetate and methanol extracts exerted inhibitory effects against H

Conclusions:

The recent findings suggest the protective effects of H. formicarum Jack. plant extracts on attenuating H

Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Asian Pacific Journal of Tropical Medicine Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Asian Pacific Journal of Tropical Medicine Year: 2018 Type: Article