Analysis of 99 patients with hematopathies and aberrations of chromosome 6 / 中华医学遗传学杂志

ABSTRACT

OBJECTIVE@#To explore the significance of chromosome 6 aberrations for the occurrence and prognosis of hematopathies.@*METHODS@#Clinical data and the cytogenetic results of 99 patients with hematopathies and aberrations of chromosome 6 were analyzed.@*RESULTS@#The patients mainly had acute lymphoblastic leukemia (ALL), lymphoma, multiple myeloma, and myelodysplastic syndrome. ALL was the most common among the selected disorders. Based on their main abnormalities, ALL patients were divided into +6/-6, 6p and 6q groups. No significant difference was found in the gender, hemoglobin and platelet count between the three groups (P> 0.05). The age and white cell count in those with 6q aberrations were significantly higher compared with the +6/-6 group (P< 0.05). Multivariate COX analysis suggested that the 6p/6q aberrations and age are risk factors for the prognosis. The 1-year overall survival rate of the 6p and 6q groups were lower than that of the +6/-6 group (P< 0.05).@*CONCLUSION@#Aberrations of chromosome 6 are common in B-cell disease, and patients with ALL and 6q aberration have a poorer prognosis. Analysis of chromosome 6 aberration has a significance for the prognosis.