Progress in metabolic engineering of biosynthesis of 3-hydroxypropionic acid / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1101-1112, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-826867
ABSTRACT
As an important platform compound, 3-hydroxypropionic acid (3-HP) can be used as a substrate to synthesize a variety of biological products with commercial potential. The titer of 3-HP by wild-type bacteria is low, which severely limits the large-scale application and production of 3-HP. By modifying the genes related to the metabolic pathway, engineered bacteria using cheap substrates as carbon sources are constructed, the aim of reducing production cost and increasing output is realized. In this paper, the recent progress in the synthesis of 3-HP by metabolic engineering at home and abroad is reviewed. The advantages and disadvantages of glycerol pathway, malonyl-CoA pathway and beta-alanine pathway for synthesis of 3-HP are also summarized and analyzed, and the future development of 3-HP is prospected.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Industrial Microbiology
/
Lactic Acid
/
Metabolic Networks and Pathways
/
Metabolic Engineering
/
Genetics
/
Glycerol
/
Metabolism
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2020
Type:
Article
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