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Advances in gene editing of Corynebacterium glutamate / 生物工程学报
Chinese Journal of Biotechnology ; (12): 820-828, 2020.
Article in Chinese | WPRIM | ID: wpr-826894
ABSTRACT
Corynebacterium glutamicum, an important microorganism to produce amino acids and organic acids, has been widely applied in food and medicine fields. Therefore, using editing tools to study the function of unknown genes in C. glutamicum has great significance for systematic development of industrial strain with efficient and novel production capability. Recently, gene editing has been greatly developed. Traditional gene editing based on homologous recombination and gene editing mediated by nuclease are successfully applied in C. glutamicum. Among these, the CRISPR system has been developed to be a main tool used for gene knockout of C. glutamicum due to its advantages of efficiency, simplicity and good target specificity. However, more efficient and reliable knockout system is still urgently demanded, to help develop high-performing strains in industrial application.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Industrial Microbiology / Glutamic Acid / Corynebacterium glutamicum / Clustered Regularly Interspaced Short Palindromic Repeats / CRISPR-Cas Systems / Gene Editing / Genetics Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Industrial Microbiology / Glutamic Acid / Corynebacterium glutamicum / Clustered Regularly Interspaced Short Palindromic Repeats / CRISPR-Cas Systems / Gene Editing / Genetics Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2020 Type: Article